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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

GSE248959 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 51 samples Submitted 2025/06/14 Platform GPL19057Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 51 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
51 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammationCell reports · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation
Madej M, Ngoc PCT, Muthukumar S et al. · Cell reports 2025 · PMID 40402745 · doi:10.1016/j.celrep.2025.115735
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248959_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1046501 and SRA study SRP474929. Searching any of these in the dataset finder brings you back here.

Samples in this study

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+ 51 more — browse all 51 samples with per-sample file links →

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