GEO series
RNA sequencing of murine NK cells treated with PGE2
GSE248977
Mus musculus
Expression profiling by high throughput sequencing
64 samples
2024/09/04
GPL19057
Summary
RNA sequencing was used to determine the impact of PGE2 signaling on NK cell function. Our analysis revealed that PGE2 induces a dysfunctional program in NK cells characterized by the inability to produce cytokines and chemokines upon their activation. Mechanistically, this program is governed by transcriptional changes downstream of the PGE2 receptors EP2 and EP4.
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