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Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communications[BAT]

GSE249028 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/07/23 Platform GPL23479
Summary
Myostatin (MSTN) has been discovered as a critical regulator of muscle mass. Recently, there has been an increasing interest in its functions in metabolism. Here, we specific knocked out MSTN in brown adipose tissue (BAT) (MSTNΔUCP1), and found that the MSTNΔUCP1 mice gained more weight than controls on high-fat diet, with progressive hepatosteatosis, and impaired skeletal muscle activity. RNA-seq analysis indicated signatures of mitochondrial dysfunction and inflammation in MSTN-ablation BAT. Further studies demonstrated that KLF4 is required for the metabolic phenotypes and FGF21 contributes to the microenvironment communication between adipocytes and macrophages induced by loss of MSTN in BAT. Moreover, MSTN-SMAD2/3-p38 signaling pathway mediated the expression of KLF4 and FGF21 in adipocytes. Taken together, brown adipocytes-derived MSTN governs metabolic niche in BAT and regulates systemic energy homeostasis.
Published in
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication
Wang H, Guo S, Gao H et al. · The Journal of clinical investigation 2024 · PMID 38889010 · doi:10.1172/JCI178303
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Also filed as BioProject PRJNA1047281 and SRA study SRP475245. Searching any of these in the dataset finder brings you back here.

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