GEO series
ATAC sequencing of murine NK cells treated with PGE2
GSE249182
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
30 samples
2024/09/04
GPL24247
Summary
ATAC sequencing was used to determine the impact of PGE2 signaling on NK cell function. Our analysis revealed that PGE2 induces a dysfunctional program in NK cells characterized by the inability to produce cytokines and chemokines upon their activation. Mechanistically, this program is governed by epigenetic changes downstream of the PGE2 receptors EP2 and EP4.
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