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An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility

GSE249251 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/15 Platform GPL24247
Summary
An unsolved mystery in biology is how human-specific traits were acquired during evolution. Here, we report that an evolutionary ancient non-coding element—human accelerated region 123 (HAR123)—has undergone rapid evolution specifically in the human lineage and confers human-specific functions. HAR123 is a neural enhancer that promotes the generation of human neuroectoderm and neural progenitor cells by upregulating the transcriptional repressor HIC1. The human and chimpanzee versions of HAR123 exhibit different properties, consistent with HAR123 being selected for new functions since the human-chimpanzee split. To address the in vivo functions of HAR123, we generated HAR123-knockout mice, which exhibit a specific defect in “re-learning.” Together, our study supports a model in which HAR123 has rapidly evolved in the human lineage to influence neural generation and, ultimately, cognitive flexibility.
Published in
An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility
Tan K, Higgins K, Liu Q et al. · Science advances 2025 · PMID 40802760 · doi:10.1126/sciadv.adt0534
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Also filed as BioProject PRJNA1048336 and SRA study SRP475598. Searching any of these in the dataset finder brings you back here.

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