← BioTransfer GEO Dataset Finder
GEO series

M2 macrophage promoting IL-10+B cell production and contribute to alleviate asthma in mouse

GSE249363 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/05/14 Platform GPL23479
Summary
B cells play a crucial regulatory role in diseases. Macrophages exist in the disease microenvironment and interact with tissue cells as well as various immune cells, but their relationship with B cells has never been reported. Using an asthma animal model and macrophage depleting agents, we found that macrophage removal significantly aggravated asthma symptoms and significantly reduced the expression of IL-10+ B cells in the asthma model. We further analyzed and found that the macrophages interacting with IL-10+ B cells in the asthma microenvironment were M2 macrophages. Moreover, through sequencing, we preliminarily found that M2 macrophages promote B cell production of IL-10 through oxidative phosphorylation pathways. Together, the results indicate that M2 macrophages act on IL-10+ B cells, thereby alleviating asthma in mouse models.
Published in
M2 macrophages promote IL-10(+)B-cell production and alleviate asthma in mice
Yu B, Wang X, Zheng Y et al. · Immunotherapy advances 2025 · PMID 40342727 · doi:10.1093/immadv/ltaf007
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE249363_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1048877 and SRA study SRP476056. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.