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AVP promotes bone marrow myelopoiesis in depression

GSE249380 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/01 Platform GPL24247
Summary
Sympathetic nerves have been implicated in the regulation of HSC homeostasis, we investigated whether sympathetic nerves regulated myeloid-biased differentiation of HSCs in CUMS mice. Transcriptome profiling (RNA-seq) and differential gene expression analysis of bone marrow cells were performed. In bone marrow cells of CUMS mice, the expression of arginine vasopressin receptor 2, a receptor of the stress-related neuroendocrine factor AVP, was upregulated through neuroactive ligand-receptor interaction pathway.
Published in
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
Mou R, Ma J, Ju X et al. · Cell stem cell 2024 · PMID 39442524 · doi:10.1016/j.stem.2024.09.018
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Also filed as BioProject PRJNA1048923 and SRA study SRP476044. Searching any of these in the dataset finder brings you back here.

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