Transcriptomic Analysis of Control and p16INK4a Knockout Mice Hearts
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Control_Young vs 4 × p16KO_Young vs 4 × Control_Old vs 4 × p16KO_OldGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- p16(INK4a) promotes myocardial ischemia-reperfusion injury by regulating bile acid transport via Slco1a4EMBO reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249775_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1050310 and SRA study SRP476723. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7964019 Control_Young_1 Control_Young
- GSM7964020 Control_Young_2 Control_Young
- GSM7964021 Control_Young_3 Control_Young
- GSM7964022 Control_Young_4 Control_Young
- GSM7964023 p16KO_Young_1 p16KO_Young
- GSM7964024 p16KO_Young_2 p16KO_Young
- GSM7964025 p16KO_Young_3 p16KO_Young
- GSM7964026 p16KO_Young_4 p16KO_Young
- GSM7964027 Control_Old_1 Control_Old
- GSM7964028 Control_Old_2 Control_Old
- GSM7964029 Control_Old_3 Control_Old
- GSM7964030 Control_Old_4 Control_Old
- GSM7964031 p16KO_Old_1 p16KO_Old
- GSM7964032 p16KO_Old_2 p16KO_Old
- GSM7964033 p16KO_Old_3 p16KO_Old
- GSM7964034 p16KO_Old_4 p16KO_Old
- GSE266882 Analysis of gastrocnemius muscle transcriptome from chow fed control and skeletal muscle HuR knockout mice with and without voluntary wheel running 56 samples shares knockout, control
- GSE325832 RNA-seq analysis of skeletal muscle from control (Cre) and Terf2 knockout (KO) mice in gastrocnemius-plantaris-soleus (GPS) and tibialis anterior (TA) 35 samples shares knockout, control
- GSE267388 mRNA expression profiles in hearts from sepsis-induced myocardial dysfunction mouse modles and controls 10 samples shares control, hearts
- GSE328885 Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice 34 samples shares knockout
- GSE217662 Decoding Trp53 regulatory program with knockout cell transcriptomic landscape analyses [scRNA-seq] 247 samples shares knockout
- GSE283201 Comparative gene expression profiling analysis of hippocampus and liver RNA-seq data for young (3-month-old) and aged (22-month-old) WT mice in both control and ethanol feeding conditions. 32 samples shares control
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares knockout
- GSE233491 Bulk TCR-sequencing of various tissues in mice treated with 2% DSS or H2O control. 45 samples shares control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.