Unveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 82 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 82 samples: 55 distinct titles, 10 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
- Paper
- Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptabilityJournal of hepatology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249859_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1051033 and SRA study SRP477257. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 82 sample titles: 55 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7957179 J85_S961_HFD [SAMPLE 1]
- GSM7957180 J20_Sas_CD [SAMPLE 2]
- GSM7957181 J7_Sas_CD [SAMPLE 3]
- GSM7957182 J20_Sas_CD [SAMPLE 4]
- GSM7957183 J85_S961_CD [SAMPLE 5]
- GSM7957184 J85_Sas_HFD [SAMPLE 6]
- GSM7957185 J7_Sas_CD [SAMPLE 7]
- GSM7957186 J7_S961_CD [SAMPLE 8]
- GSM7957187 J20_Sas_CD [SAMPLE 9]
- GSM7957188 J85_Sas_HFD [SAMPLE 10]
- GSM7957189 J20_S961_CD [SAMPLE 11]
- GSM7957190 J85_S961_CD [SAMPLE 12]
- GSM7957191 J85_S961_CD [SAMPLE 13]
- GSM7957192 J85_S961_CD [SAMPLE 14]
- GSM7957193 J85_S961_CD [SAMPLE 15]
- GSM7957194 J20_S961_CD [SAMPLE 16]
- GSM7957195 J7_Sas_CD [SAMPLE 17]
- GSM7957196 J85_Sas_CD [SAMPLE 18]
- GSM7957197 J7_Sas_CD [SAMPLE 19]
- GSM7957198 J85_Sas_HFD [SAMPLE 20]
- GSM7957199 J20_Sas_CD [SAMPLE 23]
- GSM7957200 J85_Sas_CD [SAMPLE 25]
- GSM7957201 J85_S961_HFD [SAMPLE 26]
- GSM7957202 J20_Sas_CD [SAMPLE 28]
- GSM7957203 J7_S961_CD [SAMPLE 29]
- GSM7957204 J85_S961_HFD [SAMPLE 30]
- GSM7957205 J7_Sas_CD [SAMPLE 32]
- GSM7957206 J7_S961_CD [SAMPLE 33]
- GSM7957207 J20_S961_CD [SAMPLE 34]
- GSM7957208 J20_S961_CD [SAMPLE 35]
- GSM7957209 J85_Sas_CD [SAMPLE 36]
- GSM7957210 J20_S961_CD [SAMPLE 37]
- GSM7957211 J7_S961_CD [SAMPLE 39]
- GSM7957212 J85_S961_HFD [SAMPLE 40]
- GSM7957213 J85_S961_HFD [SAMPLE 41]
- GSM7957214 J85_Sas_CD [SAMPLE 42]
- GSM7957215 J85_Sas_HFD [SAMPLE 43]
- GSM7957216 J85_Sas_CD [SAMPLE 44]
- GSM7957217 J7_S961_CD [SAMPLE 45]
- GSM7965644 K4m-1
+ 42 more — browse all 82 samples with per-sample file links →
- GSE249858 Unveiling the Molecular Legacy of Transient Insulin Resistance: Implications for Hepatic Metabolic Adaptability [RNA-Seq] 18 samples shares implications, adaptability, resistance, unveiling, transient, insulin, hepatic, legacy
- GSE270246 Hepatic insulin resistance promotes fructose-enriched diet-induced fatty liver diseases. 22 samples shares resistance, insulin, hepatic
- GSE275407 Covalent Binding of Thioredoxin to TXNIP is Required for Diet-induced Hepatic Insulin Resistance in the Liver 15 samples shares resistance, insulin, hepatic
- GSE290031 Very long-chain ceramides in skeletal muscle associate with systemic insulin resistance independent of obesity 92 samples shares resistance, insulin
- GSE286275 Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes 38 samples shares resistance, insulin
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares resistance, insulin
- GSE234483 Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan. 20 samples shares resistance, insulin
- GSE262426 Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes 16 samples shares resistance, insulin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.