GEO series
Consequences of ZNF292 deficiency for human cortical interneuron development
GSE249940
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2025/02/05
GPL24676
Summary
Human embryonic stem cell (hESC) models of ZNF292 deficiency were generated, including a KRAB-only control and two CRISPRi knockdown models (ZNF-G1 and ZNF-G2). These hESC models were used to derived MGE-like ventral telencephalic neural progenitors (day 15; D15) and cortical interneurons (day 30; D30). RNA-seq was conducted in these models to define transcriptional changes that result from ZNF292 deficiency during this process.
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Paper (PMID 40257863) ↗
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