Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and function
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 55 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 55 samples: 13 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and functionCell reports · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249942_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1051153 and SRA study SRP477398. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 52 samples.
How we read this: 13 replicated groups read from 55 sample titles; they account for 52 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7967924 D15 KRAB Sample 1 D15 KRAB Sample
- GSM7967925 D15 KRAB Sample 2 D15 KRAB Sample
- GSM7967926 D15 KRAB Sample 3 D15 KRAB Sample
- GSM7967927 D15 KRAB Sample 4 D15 KRAB Sample
- GSM7967928 D15 ZNF-G1 Sample 1 D15 ZNF-G1 Sample
- GSM7967929 D15 ZNF-G1 Sample 2 D15 ZNF-G1 Sample
- GSM7967930 D15 ZNF-G1 Sample 3 D15 ZNF-G1 Sample
- GSM7967931 D15 ZNF-G1 Sample 4 D15 ZNF-G1 Sample
- GSM7967932 D15 ZNF-G2 Sample 1 D15 ZNF-G2 Sample
- GSM7967933 D15 ZNF-G2 Sample 2 D15 ZNF-G2 Sample
- GSM7967934 D15 ZNF-G2 Sample 3 D15 ZNF-G2 Sample
- GSM7967935 D15 ZNF-G2 Sample 4 D15 ZNF-G2 Sample
- GSM7967936 D30 KRAB Sample 1 D30 KRAB Sample
- GSM7967937 D30 KRAB Sample 2 D30 KRAB Sample
- GSM7967938 D30 KRAB Sample 3 D30 KRAB Sample
- GSM7967939 D30 KRAB Sample 4 D30 KRAB Sample
- GSM7967940 D30 ZNF-G1 Sample1 D30 ZNF-G1 Sample
- GSM7967941 D30 ZNF-G1 Sample2 D30 ZNF-G1 Sample
- GSM7967942 D30 ZNF-G1 Sample3 D30 ZNF-G1 Sample
- GSM7967943 D30 ZNF-G1 Sample4 D30 ZNF-G1 Sample
- GSM7967944 D30 ZNF-G2 Sample 1 D30 ZNF-G2 Sample
- GSM7967945 D30 ZNF-G2 Sample 2 D30 ZNF-G2 Sample
- GSM7967946 D30 ZNF-G2 Sample 3 D30 ZNF-G2 Sample
- GSM7967947 D30 ZNF-G2 Sample 4 D30 ZNF-G2 Sample
- GSM7967948 D15 KRAB IgG Sample 1 D15 KRAB IgG Sample
- GSM7967949 D15 KRAB IgG Sample 2 D15 KRAB IgG Sample
- GSM7967950 D15 KRAB IgG Sample 3 D15 KRAB IgG Sample
- GSM7967951 D15 KRAB IgG Sample 4 D15 KRAB IgG Sample
- GSM7967952 D15 KRAB ZNF292 Sample 1 D15 KRAB ZNF292 Sample
- GSM7967953 D15 KRAB ZNF292 Sample 2 D15 KRAB ZNF292 Sample
- GSM7967954 D15 KRAB ZNF292 Sample 3 D15 KRAB ZNF292 Sample
- GSM7967955 D15 KRAB ZNF292 Sample 4 D15 KRAB ZNF292 Sample
- GSM7967956 D15 ZNF-G1 ZNF292 Sample 1 D15 ZNF-G1 ZNF292 Sample
- GSM7967957 D15 ZNF-G1 ZNF292 Sample 2 D15 ZNF-G1 ZNF292 Sample
- GSM7967958 D15 ZNF-G1 ZNF292 Sample 3 D15 ZNF-G1 ZNF292 Sample
- GSM7967959 D15 ZNF-G1 ZNF292 Sample 4 D15 ZNF-G1 ZNF292 Sample
- GSM7967960 D15 ZNF-G2 ZNF292 Sample 1 D15 ZNF-G2 ZNF292 Sample
- GSM7967961 D15 ZNF-G2 ZNF292 Sample 2 D15 ZNF-G2 ZNF292 Sample
- GSM7967962 D15 ZNF-G2 ZNF292 Sample 3 D15 ZNF-G2 ZNF292 Sample
- GSM7967963 D15 ZNF-G2 ZNF292 Sample 4 D15 ZNF-G2 ZNF292 Sample
+ 15 more — browse all 55 samples with per-sample file links →
- GSE249941 ZNF292 genome-wide occupancy during cortical interneuron development 31 samples shares znf292, interneuron, cortical
- GSE249940 Consequences of ZNF292 deficiency for human cortical interneuron development 24 samples shares znf292, interneuron, cortical
- GSE119316 Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder 71 samples shares neurodevelopmental, cortical
- GSE231321 Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids 30 samples shares neurodevelopmental, cortical
- GSE274986 Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration [scMultiome] 26 samples shares neurodevelopmental
- GSE262442 Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs 69 samples shares neurodevelopmental
- GSE228834 Biallelic loss-of-function variants of ZFTRAF1 cause neurodevelopmental disorder with microcephaly and hypotonia 9 samples shares neurodevelopmental
- GSE301238 SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder [fibroblast] 69 samples shares neurodevelopmental
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.