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Effect of Gsdmc knockdown in murine KPC cells transcriptome

GSE250062 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/18 Platform GPL24247
Summary
We identified that Gsdmc gene is important for pancreatic cancer in tumorigenesis and metastasis. Here we used KPC mice (LSL-KrasG12D/+; p53f/f; Pdx1-Cre)-derived cancer cells, KPC cells in short, to check the effects of Gsdmc knockdown on primary tumor growth and metastasis. The results suggested that Gsdmc knockdown inhibited the expression of key genes in multiple pathways, including cell migration, epithelial-mesenchymal transition, immune cell recruitment, and so on. The data deposited here provides the transcriptomic alteration of KPC cells after Gsdmc knockdown with two shRNAs.
Published in
Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis-Independent Mechanism
Wu R, Li J, Aicher A et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 · PMID 39297408 · doi:10.1002/advs.202308990
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Also filed as BioProject PRJNA1051955 and SRA study SRP477728. Searching any of these in the dataset finder brings you back here.

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