Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Single-cell RNA-seq · human · 23 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 23 samples: 23 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritisNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE250138_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1052093 and SRA study SRP477846. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 23 sample titles: 23 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7974475 V4_B
- GSM7974476 V6_B
- GSM7974477 V4_D
- GSM7974478 V5_A
- GSM7974479 V6_C
- GSM7974480 V6_A
- GSM7974481 V5_D
- GSM7974482 V3_A
- GSM7974483 V2_D
- GSM7974484 V4_A
- GSM7974485 V1_D
- GSM7974486 V2_C
- GSM7974487 V5_C
- GSM7974488 V5_B
- GSM7974489 V1_A
- GSM7974490 V2_B
- GSM7974491 V3_C
- GSM7974492 V3_D
- GSM7974493 V4_C
- GSM7974494 V6_D
- GSM7974495 CTRL1_B
- GSM7974496 CTRL1_C
- GSM7974497 CTRL1_D
- GSE253633 Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis 28 samples shares glomerulonephritis, profiling-based, anca-associated, ustekinumab, pathogenic, targeting
- GSE207438 Immune Profiling-Based Treatment for ANCA-Associated Glomerulonephritis with Ustekinumab 4 samples shares glomerulonephritis, profiling-based, anca-associated, ustekinumab
- GSE100833 A functional genomics predictive network model identifies regulators of inflammatory bowel disease: Microarray Analysis of Human Blood and Intestinal Biopsy Samples from a Phase 2b, Double-blind, Placebo-controlled Study of Ustekinumab in Crohn's Disease 1717 samples shares ustekinumab
- GSE206285 Efficacy and safety of ustekinumab treatment in patients with ulcerative colitis 568 samples shares ustekinumab
- GSE108112 Shared molecular targets in the tubulointerstitial transcriptome from patients with nephrotic syndrome and ANCA-associated vasculitis 169 samples shares anca-associated
- GSE108109 Shared molecular targets in the glomerular transcriptome from patients with nephrotic syndrome and ANCA-associated vasculitis 111 samples shares anca-associated
- GSE272779 Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells 12 samples shares glomerulonephritis
- GSE129752 Blood transcriptome indicates different disease etiology in pediatric ANCA-associated vasculitis subtypes. 52 samples shares anca-associated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.