GEO series
Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells
GSE272779
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/05/26
GPL24676
Summary
YAP, a transcriptional co-activator, is known to control programs that are both cell- and context-dependent. We report that the overactivation of YAP (YAP5SA) in podocytes has both cell autonomous and non-cell autonomous consequences. RNA-seq analysis of YAP5SA-expressing compared to control podocytes revealed pathways and candidate genes that could explain both these effects.
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Paper (PMID 40560996) ↗
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