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Syngeneic mouse model of YES-driven metastatic and proliferative hepatocellular carcinoma.

GSE250553 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/11 Platform GPL19057
Summary
Hepatocellular carcinoma (HCC) is a disease of high unmet medical need that has become a global health problem. The development of targeted therapies for HCC has been hindered by the incomplete understanding of HCC pathogenesis and the limited number of relevant preclinical animal models. We have recently unveiled a novel YES-dependent oncogenic signaling pathway in HCC. To model this subset of HCC, we have established a series of syngeneic cell lines from liver tumors of transgenic mice expressing activated YES. The resulting HepYF cell lines were enriched for expression of stem cell/progenitor markers, proliferated rapidly and were characterized by high SRC-family kinase activity and activated mitogenic signaling pathways. Transcriptomic analysis indicated that HepYF cells are representative of the most aggressive proliferation class G3 subgroup of HCC. HepYF cells formed rapidly growing metastatic tumors upon orthotopic implantation into syngeneic hosts.
Published in
Syngeneic mouse model of YES-driven metastatic and proliferative hepatocellular carcinoma
Voisin L, Lapouge M, Saba-El-Leil MK et al. · Disease models & mechanisms 2024 · PMID 39051113 · doi:10.1242/dmm.050553
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Also filed as BioProject PRJNA1054524 and SRA study SRP479016. Searching any of these in the dataset finder brings you back here.

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