Effects of paternal high cholesterol diet on F1 generation intimal transcriptome
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 21 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspringJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE251711_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1055100 and SRA study SRP479294. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 21 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7986347 intima LCD male rep 1 [F1LCD2]
- GSM7986348 intima LCD male rep 2 [F1LCD3]
- GSM7986349 intima LCD male rep 3 [F1LCD4]
- GSM7986350 intima LCD male rep 4 [F1LCD5]
- GSM7986351 intima LCD female rep 1 [F1LCD6]
- GSM7986352 intima LCD female rep 2 [F1LCD7]
- GSM7986353 intima LCD female rep 3 [F1LCD8]
- GSM7986354 intima LCD female rep 4 [F1LCD9]
- GSM7986355 intima LCD female rep 5 [F1LCD10]
- GSM7986356 intima LCD female rep 6 [F1LCD11]
- GSM7986357 intima LCD female rep 7 [F1LCD12]
- GSM7986358 intima HCD male rep 1 [F1HCD1]
- GSM7986359 intima HCD male rep 2 [F1HCD2]
- GSM7986360 intima HCD male rep 3 [F1HCD4]
- GSM7986361 intima HCD male rep 4 [F1HCD5]
- GSM7986362 intima HCD male rep 5 [F1HCD6]
- GSM7986363 intima HCD female rep 1 [F1HCD7]
- GSM7986364 intima HCD female rep 2 [F1HCD8]
- GSM7986365 intima HCD female rep 3 [F1HCD9]
- GSM7986366 intima HCD female rep 4 [F1HCD10]
- GSM7986367 intima HCD female rep 5 [F1HCD11]
- GSE315007 Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice. 30 samples shares cholesterol, diet
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares generation, paternal
- GSE256502 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_isolated_cells] 31 samples shares cholesterol, diet
- GSE256501 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_liver] 12 samples shares cholesterol, diet
- GSE239814 Mitochondrial signals mediate paternal effects on offspring metabolism (Smart-Seq) 221 samples shares paternal
- GSE267938 Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement 256 samples shares generation
- GSE272353 Genetic context modulates aging and degeneration in the murine retina 201 samples shares generation
- GSE291363 Mitochondrial dysfunction charachterizes the multigenerational effects of maternal obesity on MASLD 18 samples shares generation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.