Optimization of a Mouse Model of Pancreatic Cancer to More Closely Simulate the Human Phenotypes of Metastasis and Cachexia
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 22 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexiaBMC cancer · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE251864_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1055569 and SRA study SRP479527. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 10 samples read as cases, 8 as controls.
How we read this: Read from 22 sample titles: 22 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7989251 KPC A
- GSM7989252 KPC B
- GSM7989253 KPCML1 A
- GSM7989254 KPCML1 B
- GSM7989255 Control for LLC A
- GSM7989256 Control for LLC B
- GSM7989257 Tumor bearing LLC A
- GSM7989258 Tumor bearing LLC B
- GSM7989259 Control for C26 A
- GSM7989260 Control for C26 B
- GSM7989261 Tumor bearing C26 A
- GSM7989262 Tumor bearing C26 B
- GSM7989263 Control for KPP A
- GSM7989264 Control for KPP B
- GSM7989265 Tumor Bearing KPP A
- GSM7989266 Tumor bearing KPP B
- GSM7989267 Ctrl KPC_A
- GSM7989268 Ctrl KPC_B
- GSM7989269 Tumor bearing KPC with no Metastasis A
- GSM7989270 Tumor bearing KPC with no Metastasis B
- GSM7989271 Tumor bearing KPC with Metastasis A
- GSM7989272 Tumor bearing KPC with Metastasis B
- GSE324743 Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine 24 samples shares pancreatic, metastasis
- GSE287625 Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity 18 samples shares pancreatic, metastasis
- GSE324997 Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine, 2. 16 samples shares pancreatic, metastasis
- GSE218178 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance 183 samples shares pancreatic
- GSE271004 Transcriptional Analyses of Acinar- And Ductal-Cell-Derived Pancreatic Cancer 59 samples shares pancreatic
- GSE277303 Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis 42 samples shares metastasis
- GSE263963 The temporal progression of lung immune remodeling during breast cancer metastasis 38 samples shares metastasis
- GSE275728 Transcriptome analysis of pancreatic cancer cells with genetically modified Ptges or Ptger4 36 samples shares pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.