Age-related Increase of CD38 Directs Osteoclastogenic Potential of Monocytic Myeloid-Derived Suppressor Cells through Mitochondrial Dysfunction
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Age-related increase of CD38 directs osteoclastogenic potential of monocytic myeloid-derived suppressor cells through mitochondrial dysfunction in male miceAging cell · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252129_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1057839 and SRA study SRP480335. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7994813 Bone Marrow (Old O1)
- GSM7994814 Bone marrow (Old O2)
- GSM7994815 Bone marrow (Old O4)
- GSM7994816 Bone marrow (Old O5)
- GSM7994817 Bone marrow (Old O6)
- GSM7994818 Bone marrow (Old O7)
- GSM7994819 Bone marrow (Young Y10)
- GSM7994820 Bone marrow (Young Y1)
- GSM7994821 Bone marrow (Young Y2)
- GSM7994822 Bone marrow (Young Y5)
- GSM7994823 Bone marrow (Young Y6)
- GSM7994824 Bone marrow (Young Y9)
- GSE295742 Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity 12 samples shares myeloid-derived, mitochondrial, suppressor
- GSE280991 Partial restoration of the mitochondrial dysfunction by AAV-Ant1 (Slc25a4) transduction protects against dilated cardiomyopathy in Slc25a4-/- plus mtDNA mutant mice 115 samples shares mitochondrial, dysfunction
- GSE311155 Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis 57 samples shares myeloid-derived, suppressor
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares mitochondrial, dysfunction
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares mitochondrial, dysfunction
- GSE300519 Neurotoxicity, α-Synuclein Pathology, and Mitochondrial Dysfunction: A Comparative Study of Three Parkinson’s Disease Mouse Models 35 samples shares mitochondrial, dysfunction
- GSE223029 Increase of blood CSF3R+ myeloid-derived suppressor cell predicts breast cancer recurrence 24 samples shares myeloid-derived, suppressor
- GSE291086 Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease 24 samples shares mitochondrial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.