Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy
RNA-seq (gene expression) · mouse · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 23 samples: 6 × WT T1D - A vs 6 × KO Control - A vs 6 × KO T1D - A vs 5 × WT Control - AGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathyJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252292_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1059265. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 4 replicated groups read from 23 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7999092 WT Control - A1757 WT Control - A
- GSM7999093 WT Control - A3767 WT Control - A
- GSM7999094 WT Control - A3903 WT Control - A
- GSM7999095 WT Control - A3904 WT Control - A
- GSM7999096 WT Control - A3907 WT Control - A
- GSM7999097 WT T1D - A1764 WT T1D - A
- GSM7999098 WT T1D - A1787 WT T1D - A
- GSM7999099 WT T1D - A1758 WT T1D - A
- GSM7999100 WT T1D - A3905 WT T1D - A
- GSM7999101 WT T1D - A3906 WT T1D - A
- GSM7999102 WT T1D - A3909 WT T1D - A
- GSM7999103 KO Control - A3679 KO Control - A
- GSM7999104 KO Control - A3680 KO Control - A
- GSM7999105 KO Control - A3670 KO Control - A
- GSM7999106 KO Control - A3672 KO Control - A
- GSM7999107 KO Control - A3673 KO Control - A
- GSM7999108 KO Control - A3766 KO Control - A
- GSM7999109 KO T1D - A3681 KO T1D - A
- GSM7999110 KO T1D - A3682 KO T1D - A
- GSM7999111 KO T1D - A3683 KO T1D - A
- GSM7999112 KO T1D - A3674 KO T1D - A
- GSM7999113 KO T1D - A3675 KO T1D - A
- GSM7999114 KO T1D - A3676 KO T1D - A
- GSE225224 Transcriptomic analysis of peripheral neuropathy in a high-fat diet-induced mouse model of type 2 diabetes 46 samples shares neuropathy, type
- GSE263080 RNA-sea of Smad4 wild-type or Smad4 knockout KPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 44 samples shares knockout, type
- GSE262879 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice. 18 samples shares knockout, type
- GSE284475 Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia 16 samples shares neuropathy, type
- GSE202232 Comparing transcriptional profiles of type 2 innate lymphoid cells from WT and Rag1 knockout mice 12 samples shares knockout, type
- GSE173595 Gene expression data from acetaminophen-induced toxicity in wild-type and Gα12 knockout mice 12 samples shares knockout, type
- GSE183318 Next-Generation Sequencing to compare RNA transcripts between Adam19 wildtype and knockout mice 12 samples shares knockout, type
- GSE293041 Single-cell transcriptome analysis of wildtype, TREM2 knockout, GPR34 knock-out or TREM2/GPR34 double knock-out primary microglia from wildtype and APP knock-in mice (8 months) 10 samples shares knockout, type
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.