Gene expression data from acetaminophen-induced toxicity in wild-type and Gα12 knockout mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Gα12KO+APAP, live vs 3 × Gα12KO+veh, live vs 3 × WT+APAP, live vs 3 × WT+veh, liveGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Gα(12) overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulationTheranostics · 2022
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE173595_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA726239 and SRA study SRP317518. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5271568 Gα12KO+APAP, liver 1 Gα12KO+APAP, live
- GSM5271569 Gα12KO+APAP, liver 2 Gα12KO+APAP, live
- GSM5271570 Gα12KO+APAP, liver 3 Gα12KO+APAP, live
- GSM5271571 Gα12KO+veh, liver 1 Gα12KO+veh, live
- GSM5271572 Gα12KO+veh, liver 2 Gα12KO+veh, live
- GSM5271573 Gα12KO+veh, liver 3 Gα12KO+veh, live
- GSM5271574 WT+APAP, liver 1 WT+APAP, live
- GSM5271575 WT+APAP, liver 2 WT+APAP, live
- GSM5271576 WT+APAP, liver 3 WT+APAP, live
- GSM5271577 WT+veh, liver 1 WT+veh, live
- GSM5271578 WT+veh, liver 2 WT+veh, live
- GSM5271579 WT+veh, liver 3 WT+veh, live
- GSE262879 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice. 18 samples shares wild-type, knockout
- GSE296464 Transcriptomic analysis of pancreas from Elp3 epithelial-specific knockout and wild-type mice with and without caerulein treatment 16 samples shares wild-type, knockout
- GSE263080 RNA-sea of Smad4 wild-type or Smad4 knockout KPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 44 samples shares wild-type, knockout
- GSE288210 Comparative gene expression profiling of RNA-seq data from islets of β-cell-specific ZZEF1 knockout mice (βZKO-Mip) and their littermate controls, treated with either azoramide or DMSO. 11 samples shares knockout
- GSE317602 Lung gene expression in WT and estrogen receptor alpha and beta knockout mice exposed to house dust mites 72 samples shares knockout
- GSE186648 Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing. 25 samples shares knockout
- GSE330380 The effects of adiponectin knockout on hepatic gene expression in male and female C57BL/6NCrl mice fed ad libitum or undergoing caloric restriction 22 samples shares knockout
- GSE284373 The effect of STING knockout on gene expression in cholestatic mice 20 samples shares knockout
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.