Comparing gene expression in ABT-199 (venetoclax) sensitive and resistant diffuse large B cell lymphoma cell (DLBCL) lines
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Diffuse large B-cell lymphomaThis series is part of our curated briefing on it.
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Identifying Targetable Vulnerabilities to Circumvent or Overcome Venetoclax Resistance in Diffuse Large B-Cell LymphomaCancers · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252306_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1059617 and SRA study SRP480806. Searching any of these in the dataset finder brings you back here.
The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Sample titles run CE-7 … CE-30 and carry no group information.
- GSM7999243 CE-7
- GSM7999244 CE-8
- GSM7999245 CE-9
- GSM7999246 CE-10
- GSM7999247 CE-11
- GSM7999248 CE-12
- GSM7999249 CE-25
- GSM7999250 CE-26
- GSM7999251 CE-27
- GSM7999252 CE-28
- GSM7999253 CE-29
- GSM7999254 CE-30
- GSE280799 Expression Data from DLBCL Cell Line U2932 (Parental, CDC-Treated, and CDC-Resistant) and 8 DLBCL Patient Samples (5 High CDC-Sensitive, 3 Low CDC-Sensitive) 20 samples same disease briefing · shares dlbcl, sensitive, resistant
- GSE283388 Gene Expression Profiling in Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines Treated with Selinexor 12 samples same disease briefing · shares dlbcl, lymphoma, diffuse
- GSE267421 Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors to venetoclax 9 samples same disease briefing · shares dlbcl, venetoclax, resistant
- GSE280321 USP13 dictates RAN turnover and vulnerability to ferroptosis in diffused large B cell lymphoma (DLBCL) 4 samples same disease briefing · shares dlbcl, lymphoma, diffuse
- GSE262641 Discovery of golcadomide (CC-99282) as a promising drug candidate for diffuse large B-cell lymphoma (DLBCL) 6 samples same disease briefing · shares dlbcl, lymphoma, diffuse
- GSE193566 Longitudinal gene expression profiling identifies a poor risk subset of patients with ABC-type Diffuse Large B Cell Lymphoma 76 samples same disease briefing · shares lymphoma, diffuse
- GSE262621 Gene expression profiling of HIV-associated diffuse large B-cell lymphomas from Malawi 70 samples same disease briefing · shares lymphoma, diffuse
- GSE213555 Molecular and pathological characterisation of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome 41 samples same disease briefing · shares lymphoma, diffuse
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.