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Molecular profiling of brainstem peptidergic neurons

GSE252409 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/03 Platform GPL24247
Summary
Hunger is a fundamental drive, evolutionarily hard-wired to ensure that an animal has sufficient energy to survive and reproduce. Just as important as knowing when to eat is for an animal to know when not to eat. Here, using spatially resolved, single cell translational phenotyping and ensemble-level molecular profiling, we characterize a small population of neuropeptidergic neurons in the brainstem’s dorsal raphe nucleus (DRN) and describe how they regulate appetite. Together, this work identifies a likely conserved cellular mechanism that transforms diverse neurohumoral signals into a key behavioral output.
Published in
Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation
Chowdhury S, Kamatkar NG, Wang WX et al. · Cell 2025 · PMID 39914383 · doi:10.1016/j.cell.2025.01.018
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Also filed as BioProject PRJNA1060350 and SRA study SRP481036. Searching any of these in the dataset finder brings you back here.

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