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Decoding Dengue's Neurological Assault: Insights from Single-Cell CNS Analysis in a Mouse Model

GSE252515 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/12 Platform GPL24247
Summary
Dengue encephalitis, as one of the severe neurological manifestations of dengue virus infection, increasingly recognized for its rising incidence and significant public health implications. However, the pathophysiological mechanisms underlying dengue encephalitis remain inadequately elucidated, and effective prophylactic or therapeutic strategies are notably absent. In this study, we employed single-nucleus RNA sequencing to construct a comprehensive atlas of dengue encephalitis, utilizing brain tissues from dengue virus-infected murine models.
Published in
Decoding dengue's neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model
Qiu M, Zhao L, Li X et al. · Journal of neuroinflammation 2025 · PMID 40038739 · doi:10.1186/s12974-025-03383-w
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Direct links to NCBI, no account and no request form: the whole study as GSE252515_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1061062 and SRA study SRP481596. Searching any of these in the dataset finder brings you back here.

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