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RNA-Seq results of a neuronal cell model of SBMA, AR-97Q cells, compared to AR-24Q cells

GSE252533 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/11/05 Platform GPL21626
Summary
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by a polyglutamine expansion in the androgen receptor (AR). Transcriptional changes were compared between a muscle cell model of SBMA (AR-97Q cells) and a control model (AR-24Q cells). RNA-seq gene expression analysis revealed that differentially expressed genes were associated with upregulation of transforming growth factor β (TGFβ) signaling, mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF) signaling, calcium signaling, and NFκB signaling.
Published in
Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models
Sakakibara K, Tanaka K, Iida M et al. · Disease models & mechanisms 2025 · PMID 40474744 · doi:10.1242/dmm.052220
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Also filed as BioProject PRJNA1061129 and SRA study SRP481456. Searching any of these in the dataset finder brings you back here.

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