Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy [RNA-Seq]
RNA-seq (gene expression) · mouse · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 17 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathyAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294261_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1248894 and SRA study SRP577682. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 17 samples.
How we read this: 6 replicated groups read from 17 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8901194 male-KO-PBS.751 male-KO-PBS
- GSM8901195 male-KO-PBS.752 male-KO-PBS
- GSM8901196 male-KO-PBS.753 male-KO-PBS
- GSM8901197 male-WT-PBS.791 male-WT-PBS
- GSM8901198 male-WT-PBS.792 male-WT-PBS
- GSM8901199 male-WT-PBS.793 male-WT-PBS
- GSM8901200 female-KO-Tau.314 female-KO-Tau
- GSM8901201 female-KO-Tau.324 female-KO-Tau
- GSM8901202 female-KO-Tau.325 female-KO-Tau
- GSM8901203 male-KO-Tau.711 male-KO-Tau
- GSM8901204 male-KO-Tau.712 male-KO-Tau
- GSM8901205 male-KO-Tau.713 male-KO-Tau
- GSM8901206 female-WT-Tau.331 female-WT-Tau
- GSM8901207 female-WT-Tau.341 female-WT-Tau
- GSM8901208 male-WT-Tau.771 male-WT-Tau
- GSM8901209 male-WT-Tau.772 male-WT-Tau
- GSM8901210 male-WT-Tau.773 male-WT-Tau
- GSE294332 Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy 49 samples shares acss2, resilience, multiomic, alzheimer, tauopathy, neuronal, confers
- GSE294751 Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy [ChIP-seq] 20 samples shares acss2, resilience, multiomic, alzheimer, tauopathy, neuronal, confers
- GSE76853 Acetyl-CoA metabolism by ACSS2 regulates neuronal histone acetylation and long-term memory [RNA-seq] 16 samples shares acss2, neuronal, rna-seq
- GSE297743 APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition [bulk RNA-seq] 28 samples shares resilience, confers, rna-seq
- GSE241770 ACSS2 mediates an epigenetic pathway to regulate maternal Beta-cell adaptation and progression of gestational diabetes (scRNA-Seq) 7899 samples shares acss2, rna-seq
- GSE98969 Single cell RNA-seq identifies a unique microglia type associated with Alzheimer’s disease [RNA] 97 samples shares alzheimer, rna-seq
- GSE234245 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target [RNA-Seq] 79 samples shares multiomic, rna-seq
- GSE254104 Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model [snRNAseq] 27 samples shares alzheimer, tauopathy
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.