GEO series
The Transcriptome of MHV or PVM Infected RAW264.7 Cell
GSE252673
Mus musculus
Expression profiling by high throughput sequencing
45 samples
2025/02/12
GPL24247
Summary
In the current in vitro research, murine macrophage RAW 264.7 cell were infected by mouse hepatitis virus, a coronavirus existed in mouse. The transcriptome analysis showed the differential expressed genes(DEG) related to important cellular physiological activity. In addition, DEGs related to metabolism and histone modification were detected, which might correlate with the trained immunity of macrophages. The current in vitro viral infection study showed the key innated immunity character of macrophages, which suggest the replacement value of viral infection cells model, to reduce the animal usage in preclinical researches.
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Paper (PMID 38992966) ↗
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