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Effects of Myotonic Dystrophy (DM1) models on hepatocyte transcriptomes

GSE252827 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/26 Platform GPL24247
Summary
Myotonic Dystrophy (DM1), a common neuromuscular disease, has been shown to have detrimental effects on the livers of patients. To study whether DM1 is directly altering liver function or whether these effects are secondary to DM1 induced functional changes in other tissues, we sequenced the transcriptomes of hepatocytes from liver-specific and whole-body murine models of DM1. We found substantial transcriptomic alteration in the liver-specific model, along with distinguishable physiological changes in the livers of both the liver-specific and whole-body models. This data serves as a survey of transcriptomic alterations in occurring in the livers of DM1 patients.
Published in
Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy
Dewald Z, Adesanya O, Bae H et al. · Nature communications 2024 · PMID 39433769 · doi:10.1038/s41467-024-53378-z
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Also filed as BioProject PRJNA1062783 and SRA study SRP482759. Searching any of these in the dataset finder brings you back here.

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