Myeloid and lymphoid lineage C9orf72 regulates the IL-17 inflammatory axis in mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Myeloid and lymphoid expression of C9orf72 regulates IL-17A signaling in miceScience translational medicine · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252888_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1062917 and SRA study SRP482776. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE334847 Hypoxic preconditioning attenuates renal ischemia–reperfusion injury by suppressing the IL-17A/IL-17RA/TRAF6 inflammatory axis 12 samples shares il-17, axis
- GSE314668 Targeting cathepsin B alleviates activation of IL-17A-netrophils axis to suppress atopic dermatitis 12 samples shares il-17, axis
- GSE247462 An enriched circulating extracellular vesicle microRNA, miR-451a, attenuates the RORγt expression in T cells in secondary lymphoid tissues, thereby ameliorating IL-17A-mediated allergic responses 12 samples shares il-17, lymphoid
- GSE341526 Atractylenolide III Alleviates Cisplatin-Induced Acute Liver Injury by Regulating Gut-Liver Axis Through Inhibiting ACT1/TRAF6/NF-κB-Mediated IL-17 Pathway 9 samples shares il-17, axis
- GSE264595 The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia (RNA-Seq) 18 samples shares myeloid, axis
- GSE221283 Parenchymal damage and myeloid inflammation link the Rag GTPase – mTORC1 axis to mammalian aging [old] 10 samples shares myeloid, axis
- GSE319397 Particle Reprogramming of the TLR–Ferroptosis Axis and Immunometabolic Pathways Inhibits Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer 9 samples shares myeloid, axis
- GSE343043 Disease context dictates the cellular targets of IL-17 in inflammatory skin disease 29 samples shares il-17
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.