Toggling of BRD4 functions is triggered through its phosphorylation by JNK [RNA-seq]
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phosphorylation by JNK switches BRD4 functionsMolecular cell · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252980_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1063371 and SRA study SRP483060. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 3 samples read as cases, 6 as controls.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8011817 Control empty vector transfected cells, biol rep1 Control empty vector tr…
- GSM8011818 Control empty vector transfected cells, biol rep2 Control empty vector tr…
- GSM8011819 Control empty vector transfected cells, biol rep3 Control empty vector tr…
- GSM8011820 WT BRD4 transfected cells, biol rep 1 WT BRD4 transfected cel…
- GSM8011821 WT BRD4 transfected cells, biol rep 2 WT BRD4 transfected cel…
- GSM8011822 WT BRD4 transfected cells, biol rep 3 WT BRD4 transfected cel…
- GSM8011823 3A-BRD4 transfected cells, biol rep 1 3A-BRD4 transfected cel…
- GSM8011824 3A-BRD4 transfected cells, biol rep 2 3A-BRD4 transfected cel…
- GSM8011825 3A-BRD4 transfected cells, biol rep 3 3A-BRD4 transfected cel…
- GSM8011826 Control empty vector transfected cells, Anisomycin treated ,biol rep1 Control empty vector tr…
- GSM8011827 Control empty vector transfected cells, Anisomycin treated ,biol rep2 Control empty vector tr…
- GSM8011828 Control empty vector transfected cells, Anisomycin treated ,biol rep3 Control empty vector tr…
- GSM8011829 WT BRD4 transfected cells, Anisomycin treated ,biol rep1 WT BRD4 transfected cel…
- GSM8011830 WT BRD4 transfected cells, Anisomycin treated ,biol rep2 WT BRD4 transfected cel…
- GSM8011831 WT BRD4 transfected cells, Anisomycin treated ,biol rep3 WT BRD4 transfected cel…
- GSM8011832 3A-BRD4 transfected cells,anisomycin treated, biol rep 1 3A-BRD4 transfected cel…
- GSM8011833 3A-BRD4 transfected cells,anisomycin treated, biol rep 2 3A-BRD4 transfected cel…
- GSM8011834 3A-BRD4 transfected cells,anisomycin treated, biol rep 3 3A-BRD4 transfected cel…
- GSE252982 Toggling of BRD4 functions is triggered through its phosphorylation by JNK. 52 samples shares brd4, jnk, phosphorylation, functions, triggered, toggling
- GSE265762 Individual RNA-seq for different prostate cancer cells and Lucap145.2 PDX treated by JQ1, AZD5153,ENZ or by FOXA1 and BRD4 gene knockdown 20 samples shares brd4, rna-seq
- GSE272018 BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection 15 samples shares brd4, functions
- GSE298837 Blocking PD-1 engagement rapidly upregulates innate antiviral and immune functions that associate with HIV reservoir decay [bulkRNA-seq] 49 samples shares functions, rna-seq
- GSE323995 CReP-mediated control of eIF2a phosphorylation is a central node in high-risk medulloblastoma [RNA-Seq 3] 48 samples shares phosphorylation, rna-seq
- GSE298838 Blocking PD-1 engagement rapidly upregulates innate antiviral and immune functions that associate with HIV reservoir decay [scRNA-seq] 38 samples shares functions, rna-seq
- GSE232879 Serine/Threonine Phosphorylation of RUNX1 Promotes Megakaryocytic Fate in Megakaryocyte-Erythroid Progenitors (Primary Human Bulk mRNA-seq) 22 samples shares phosphorylation, rna-seq
- GSE272848 Overlapping and distinctfunctions of SPT6, PNUTS and PCF11 in regulating transcription termination [RNA-Seq] 21 samples shares functions, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.