Toggling of BRD4 functions is triggered through its phosphorylation by JNK [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 22 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 22 samples: 22 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phosphorylation by JNK switches BRD4 functionsMolecular cell · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252981_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1063372 and SRA study SRP483503. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 8 as controls.
How we read this: Read from 22 sample titles: 22 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8011835 Control empty vector transfected cells, biol rep1, ChIP
- GSM8011836 Control empty vector transfected cells, biol rep2, ChIP
- GSM8011837 WT BRD4 transfected cells, biol rep 1, ChIP
- GSM8011838 WT BRD4 transfected cells, biol rep 2, ChIP
- GSM8011839 3A-BRD4 transfected cells, biol rep 1, ChIP
- GSM8011840 3A-BRD4 transfected cells, biol rep 2, ChIP
- GSM8011841 Control empty vector transfected cells, Anisomycin treated ,biol rep1, ChIP
- GSM8011842 Control empty vector transfected cells, Anisomycin treated ,biol rep2, ChIP
- GSM8011843 WT BRD4 transfected cells, Anisomycin treated ,biol rep1, ChIP
- GSM8011844 WT BRD4 transfected cells, Anisomycin treated ,biol rep2, ChIP
- GSM8011845 3A-BRD4 transfected cells,anisomycin treated, biol rep 1, ChIP
- GSM8011846 Control empty vector transfected cells, biol rep1, input
- GSM8011847 Control empty vector transfected cells, biol rep2, input
- GSM8011848 WT BRD4 transfected cells, biol rep 1, input
- GSM8011849 WT BRD4 transfected cells, biol rep 2, input
- GSM8011850 3A-BRD4 transfected cells, biol rep 1, input
- GSM8011851 3A-BRD4 transfected cells, biol rep 2, input
- GSM8011852 Control empty vector transfected cells, Anisomycin treated ,biol rep1, input
- GSM8011853 Control empty vector transfected cells, Anisomycin treated ,biol rep2, input
- GSM8011854 WT BRD4 transfected cells, Anisomycin treated ,biol rep1, input
- GSM8011855 WT BRD4 transfected cells, Anisomycin treated ,biol rep2, input
- GSM8011856 3A-BRD4 transfected cells,anisomycin treated, biol rep 1, input
- GSE252982 Toggling of BRD4 functions is triggered through its phosphorylation by JNK. 52 samples shares brd4, jnk, phosphorylation, functions, triggered, toggling
- GSE232371 Genome-wide studies identify genes directly regulated by PML_RARα fusion protein and co-activator BRD4 [ChIP-Seq] 17 samples shares brd4, chip-seq
- GSE265759 Individual ChIP-seq for BRD4 and H3K27ac 16 samples shares brd4, chip-seq
- GSE272018 BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection 15 samples shares brd4, functions
- GSE265881 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (ChIP-Seq) 72 samples shares phosphorylation, chip-seq
- GSE324916 Phosphorylation of serines 287/288 in DEK regulates cell-type-specific chromatin occupancy and compaction [ChIP-Seq] 24 samples shares phosphorylation, chip-seq
- GSE272847 Overlapping and distinctfunctions of SPT6, PNUTS and PCF11 in regulating transcription termination [ChIP-Seq] 11 samples shares functions, chip-seq
- GSE285137 A phosphorylation switch within the Mediator subunit MED15 controls cellular senescence and cognitive decline [ChIP-seq] 10 samples shares phosphorylation, chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.