GEO series
Ca2+ influx through ORAI1 and ORAI2 channels regulates chromatin accessibility in CD4+ T cells
GSE253187
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
13 samples
2025/01/01
GPL24247
Summary
Activation of CD4+ T cells by T cell receptor (TCR) signaling results in altered gene expression as a result of epigenetic and transcriptional regulation. A critical TCR signaling pathway in CD4+ T cells is driven by Ca2+ influx across the plasma membrane through Ca2+ release-activated Ca2+ (CRAC) channels that are formed by ORAI1 and ORAI2 proteins. Here we analyzed the effects of suppressing Ca2+ influx in mouse CD4+ T cells on chromatin accessibility by genetically deleting the ORAI1 channel alone or both ORAI1 and ORAI2 channels. CD4+ T cells specific for ovalbumin (OVA) from TCR transgenic OT-II were activated by in vivo exposure to influenza A virus (IAV) expressing OVA neoantigen. Changes in chromatin accessibility of CD4+ T cells in response to IAV-OVA infection were determined by ATAC sequencing
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