Transcriptional profiling of CD11b+ microglia isolated from cerebellum and olfactory bulb-removed brains of SAMP8 and SAMR1 mice at 2, 5, and 9 months of age.
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging miceAging cell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE253582_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1066315 and SRA study SRP484547. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8023836 9-months SAMR1, GEX
- GSM8023837 9-months SAMR1, ADT
- GSM8023838 9-months SAMR1,HTO
- GSM8023839 9-months SAMP8, GEX
- GSM8023840 9-months SAMP8, ADT
- GSM8023841 9-months SAMP8,HTO
- GSM8023842 5-months SAMR1, GEX
- GSM8023843 5-months SAMR1, ADT
- GSM8023844 5-months SAMR1,HTO
- GSM8023845 5-months SAMP8, GEX
- GSM8023846 5-months SAMP8, ADT
- GSM8023847 5-months SAMP8,HTO
- GSM8023848 2-months SAMR1, GEX
- GSM8023849 2-months SAMR1, ADT
- GSM8023850 2-months SAMR1,HTO
- GSM8023851 2-months SAMP8, GEX
- GSM8023852 2-months SAMP8, ADT
- GSM8023853 2-months SAMP8,HTO
- GSE253581 Transcriptional profiling of CD11b+ microglia isolated from cerebellum and olfactory bulb-removed brains of K18-seeded P301L, PBS-injected P301L and PBS-injected FVB at 1-week, 1-month, and 3-months post-injection. 27 samples shares cd11b, bulb-removed, cerebellum, microglia, olfactory, isolated
- GSE283401 Gene expression profile of Fcrls+/CD11b+/Ly6C- microglia from young and old mice after abdominal surgery 96 samples shares cd11b, microglia
- GSE295287 Transcriptomic profiling of CD11b+F4/80+CD206+ TAMs isolated from tumor-bearing mice treated with vehicle or TP-18. 6 samples shares cd11b, isolated
- GSE241877 Gene expression profile at the single cell level of CD45+ CD11b+ cells isolated from the brain and bone marrow of mice either untreated or conditioned and transplanted with total bone marrow. 4 samples shares cd11b, isolated
- GSE261246 Gene expression profile at the single cell level of CD45+ CD11b+ cells isolated from the brain and bone marrow of mice either untreated or conditioned and transplanted with mouse hematopoietic stem and progenitor cells (HSPCs) expanded in culture. 4 samples shares cd11b, isolated
- GSE337798 XCR1+ and CD11b+ migratory dendritic cells cooperate for the crosspriming of intratumoral CD8+ T cells with a tissue-resident memory phenotype 10 samples shares cd11b
- GSE291447 Targeting CD11b+ regulatory B cells via RAS/RAF/PI3K pathway inhibition augments response to immune checkpoint blockade or CD40 agonism in metastatic melanoma 60 samples shares cd11b
- GSE244652 Transcriptional profiling of myeloid cells (CD11b) and astrocytes (ACSA2) from the striatum and the midbrain of control and parkinsonian animals in the MPTP mouse model 48 samples shares cd11b
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.