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Transcriptomic analysis of fetal epaxial muscle fibers from wildtype and dyW/dyW mice at embryonic day 17.5

GSE253680 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/09/23 Platform GPL30172
Summary
LAMA2-congenital muscular dystrophy (LAMA2-CMD) is the most common congenital muscular dystrophy and is triggered by mutations in LAMA2, coding for laminin α2 chain. Several phenotypes have been associated with LAMA2-CMD, including inflammation, fibrosis and increased oxidative stress. However, it is not yet known what mechanisms are faulty, right at disease onset, which in the mouse model of LAMA2-CMD dyW/dyW has been previously established to occur between embryonic days (E) 17.5 and E18.5. This transcriptomic analysis of fetal muscle fibers perfomed at E17.5 provides critical information regarding the genes and pathways that are altered in LAMA2-CMD right at the onset of the disease.
Published in
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms
Martins SG, Ribeiro V, Melo C et al. · Life science alliance 2024 · PMID 39379105 · doi:10.26508/lsa.202402829
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Also filed as BioProject PRJNA1066760 and SRA study SRP484826. Searching any of these in the dataset finder brings you back here.

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