Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption
RNA-seq (gene expression) · human · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 32 samples: 21 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Heterogeneous Cardiac-Derived and Neural Crest-Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling DisruptionArteriosclerosis, thrombosis, and vascular biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE253935_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1067696 and SRA study SRP485296. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 32 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8030565 Root-Wnt1-Cre2
- GSM8030566 Asc-GFP-Wnt1-Cre2
- GSM8030567 Asc-RFP-Wnt1-Cre2
- GSM8030568 Arch-GFP-Wnt1-Cre2
- GSM8030569 Root-GFP-Nkx2-5-Cre
- GSM8030570 Root-RFP-Nkx2-5-Cre
- GSM8030571 Asc-GFP-Nkx2-5-Cre
- GSM8030572 Asc-RFP-Nkx2-5-Cre
- GSM8030573 Arch-RFP-Nkx2-5-Cre
- GSM8030574 Desc-RFP-Nkx2-5-Cre
- GSM8030575 Ascending_C14
- GSM8030576 Root_C15
- GSM8030577 Ascending_C16
- GSM8030578 Arch_C17
- GSM8030579 Descending_C18
- GSM8030580 Root_C21
- GSM8030581 Ascending_C22
- GSM8030582 Arch_C23
- GSM8030583 Root_C27
- GSM8030584 Ascending_C28
- GSM8030585 Arch_C29
- GSM8030586 Descending_C30
- GSM8030587 Root_C45
- GSM8030588 Ascending_C46
- GSM8030589 Root_C52
- GSM8030590 H137Root
- GSM8030591 H137Asc
- GSM8030592 H137Arch
- GSM8030593 H143Root
- GSM8030594 H143Asc
- GSM8030595 H143Arch
- GSM8030596 H143Desc
- GSE270713 Psychological stress increases susceptibility to Staphylococcus aureus infection by the action of TGFβ to suppress immune acting fibroblasts [RNA-Seq] 36 samples shares tgf
- GSE273561 Aldehydes alter TGF-β signaling and induce obesity and cancer 27 samples shares tgf
- GSE241047 PRDM16 deficiency triggered by TGF-β1 signaling promotes aberrant mitochondrial homeostasis and kidney fibrosis 11 samples shares tgf
- GSE266135 Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma 90 samples shares disruption
- GSE66383 Disruptions of Topological Chromatin Domains Causes Pathogenic Rewiring of Gene-Enhancer Interactions 31 samples shares disruption
- GSE225993 Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [ATAC-seq] 16 samples shares disruption
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.