GEO series
Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [ATAC-seq]
GSE225993
Homo sapiens; Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
16 samples
2024/03/12
GPL16791GPL17021
Summary
To investigate changes in chromatin landscape and nucleosome positioning in response to SF3B1 mutations, we peformed ATAC seq in K562, human CD34, and murine cKit+,Sca1+,Lin- cells We then performed peak-based and nucleosome positioning analyses using data obtained from ATAC to investigate changes in chromatin accessibility and promoter nucleosome occupancy, respectively
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Paper (PMID 38521065) ↗
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