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Effect of PME-1 S156A mutant on gene expression of mouse brain

GSE254226 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/02/29 Platform GPL24247
Summary
Protein methylation is a reversible post-translational modification commonly occurring on carboxyl groups of leucine, glutamate, and isoprenylated cysteine, or the side-chain nitrogen atoms of arginine, lysine, and histidine residues. Histone methylation is well studied and shown to play a central role in the regulation of epigenetic gene expression. On the other hand, our knowledge of the importance of methylation in proteins other than histones is limited. Increased PME-1 expression and decreased LCMT-1 expression associated with decreased PP2Ac methylation levels were observed in the brain of AD patients. Therefore, it is crucial to understand the precise role of PP2A methylation in physiological and pathophysiological processes.To obtain a comprehensive view for the effect of loss of PME-1 methylesterase activity on brain development, we performed transcriptome analysis for E18.5 brain tissues.
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Direct links to NCBI, no account and no request form: the whole study as GSE254226_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1069043 and SRA study SRP486027. Searching any of these in the dataset finder brings you back here.

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