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RNAseq anaylsis of three Islet-1+ Cardiac Stem Cell Clones derived from Neonatal Cardiac Tissue

GSE254267 Homo sapiens Expression profiling by high throughput sequencing 3 samples Submitted 2026/01/28 Platform GPL17303
Summary
Islet-1+ Cardiac Stem Cells (CSCs) derived from neonatal cardiac tissue are promising candidates for cardiac repair due to their ability to differentiate into all cells of the cardiovascular lineage and the innate ability of the neonatal heart to regenerate after injury. In this study we analyzed the transcriptome and differentiation capability of Islet-1+ cardiac progenitor cell clones isolated from neonatal human patient-derived tissue and demonstrated that matched ovine CSCs restore function when administered for cell-based repair in an allogeneic ovine model of myocardial infarction.
Published in
Neonatally-derived multipotent Islet-1+ Mesp1+FOXA2+ stem cell clones restore cardiac function in sheep
Hughes L, Baio J, Hasaniya N et al. · Frontiers in cardiovascular medicine 2025 · PMID 41561127 · doi:10.3389/fcvm.2025.1671367
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Also filed as BioProject PRJNA1069108 and SRA study SRP485967. Searching any of these in the dataset finder brings you back here.

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