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A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny [Single-cell RNA + ATAC-Seq]

GSE254290 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/03/12 Platform GPL28457
Summary
We performed 10x single cell multiome analysis (ATAC-seq + RNA-seq) on fetal wild-type and E47-/- N1End/d thymic cells to decipher the dynamics of chromatin structure and gene expression during thymic ontogeny.
Published in
A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny
Miyazaki K, Horie K, Watanabe H et al. · Genes & development 2025 · PMID 39904558 · doi:10.1101/gad.352111.124
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Also filed as BioProject PRJNA1069642 and SRA study SRP486120. Searching any of these in the dataset finder brings you back here.

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