Epigenetic regulation of chromosomal instability by EZH2 methyltransferase [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × D7-GFP-_DMSO vs 3 × D7-GFP-_EPZ vs 3 × D7-GFP_plus_DMSO vs 3 × D7-GFP_plus_EPZGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic Regulation of Chromosomal Instability by EZH2 MethyltransferaseCancer discovery · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE254325_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1069751 and SRA study SRP486155. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8037759 D7-GFP-_DMSO D7-GFP-_DMSO
- GSM8037760 D7-GFP-_DMSO replicate 2 D7-GFP-_DMSO
- GSM8037761 D7-GFP-_DMSO replicate 3 D7-GFP-_DMSO
- GSM8037762 D7-GFP-_EPZ D7-GFP-_EPZ
- GSM8037763 D7-GFP-_EPZ replicate 2 D7-GFP-_EPZ
- GSM8037764 D7-GFP-_EPZ replicate 3 D7-GFP-_EPZ
- GSM8037765 D7-GFP_plus_DMSO D7-GFP_plus_DMSO
- GSM8037766 D7-GFP_plus_DMSO replicate 2 D7-GFP_plus_DMSO
- GSM8037767 D7-GFP_plus_DMSO replicate 3 D7-GFP_plus_DMSO
- GSM8037768 D7-GFP_plus_EPZ D7-GFP_plus_EPZ
- GSM8037769 D7-GFP_plus_EPZ replicate 2 D7-GFP_plus_EPZ
- GSM8037770 D7-GFP_plus_EPZ replicate 3 D7-GFP_plus_EPZ
- GSE254328 Epigenetic regulation of chromosomal instability by EZH2 methyltransferase 26 samples shares ezh2, methyltransferase, chromosomal, instability, epigenetic
- GSE254324 Epigenetic regulation of chromosomal instability by EZH2 methyltransferase [CUT&RUN] 14 samples shares ezh2, methyltransferase, chromosomal, instability, epigenetic
- GSE298836 Loss of Histone Methyltransferase Ezh2 Exacerbates Polarization of Macrophages toward M2-Like Phenotypes by Hepatocellular Carcinoma [RNA-Seq] 14 samples shares ezh2, methyltransferase, rna-seq
- GSE280300 Vhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [bulk RNA-seq] 24 samples shares chromosomal, instability, rna-seq
- GSE280281 Vhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [scRNA-seq] 16 samples shares chromosomal, instability, rna-seq
- GSE302602 Dominant negative effects of Weaver syndrome-associated EZH2 variants [RNA-seq] 54 samples shares ezh2, rna-seq
- GSE266586 RNA-seq in murine LSKs after Cux1 and/or Ezh2 loss, in the presence or absence of the DNA damaging agent N-ethyl-N-nitrosourea 39 samples shares ezh2, rna-seq
- GSE291454 A conserved function of EZH2-PRC2 in the repression of primitive endoderm cell fate [RNA-Seq - mouse] 22 samples shares ezh2, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.