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Intestinal NSD2 aggravates hepatic steatosis during obesity through histone modifications [RNA-seq]

GSE254667 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/01 Platform GPL24247
Summary
The impairment of the intestinal barrier will lead to the accumulation of fat and harmful substances in the liver, inducing hepatic steatosis or steatohepatitis. Zhang et al. identified NSD2 in the intestine as a novel and essential regulator of hepatic steatosis. NSD2 directly regulates transcriptional activation of ERN1 through the modification of H3 dimethylated on lysine 36 (H3K4me36), thereby activating the ERN1-JNK axis to induce inflammatory response, intestinal barrier impairment, and hepatic steatosis. This functional mechanism of NSD2 provides a potential therapeutic target for this disease.
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Also filed as BioProject PRJNA1071485 and SRA study SRP487058. Searching any of these in the dataset finder brings you back here.

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