Lin28A Overexpression Triggers Inflammatory Response in Mouse Kidneys
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nephron-Specific Lin28A Overexpression Triggers Severe Inflammatory Response and Kidney DamageInternational journal of biological sciences · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE254805_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1071984 and SRA study SRP487384. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8057951 week1 Transgen rep1 week1 Transgen
- GSM8057952 week1 Transgen rep2 week1 Transgen
- GSM8057953 week1 Transgen rep3 week1 Transgen
- GSM8057954 week1 WT rep1 week1 WT
- GSM8057955 week1 WT rep2 week1 WT
- GSM8057956 week1 WT rep3 week1 WT
- GSM8057957 week2 Transgen rep1 week2 Transgen
- GSM8057958 week2 Transgen rep2 week2 Transgen
- GSM8057959 week2 Transgen rep3 week2 Transgen
- GSM8057960 week2 WT rep1 week2 WT
- GSM8057961 week2 WT rep2 week2 WT
- GSM8057962 week2 WT rep3 week2 WT
- GSM8057963 week5 Transgen rep1 week5 Transgen
- GSM8057964 week5 Transgen rep2 week5 Transgen
- GSM8057965 week5 Transgen rep3 week5 Transgen
- GSM8057966 week5 WT rep1 week5 WT
- GSM8057967 week5 WT rep2 week5 WT
- GSM8057968 week5 WT rep3 week5 WT
- GSE169555 Embryonic lumenogenesis is controlled by selective mRNA decay triggered by LIN28A relocation 146 samples shares lin28a
- GSE297493 Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers pre-clinical autoimmunity 14 samples shares triggers
- GSE306869 The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation 24 samples shares lin28a
- GSE262720 Gene expression data of Lin28a-positive MuSCs using RNA-seq and RIP-seq 14 samples shares lin28a
- GSE271598 Transcriptional Dysregulation in the Hippocampus of a Mouse Model for Parkinson's - Linked Cognitive Decline is Driven by Sex, Age, and Alpha-synuclein overexpression 64 samples shares overexpression
- GSE220322 Gene expression in pre-cystic mouse kidneys after Pkd2 deletion. 48 samples shares kidneys
- GSE336380 Knockdown and overexpression of injury-responsive transcription factors in cultures of adult mouse dorsal root ganglia 48 samples shares overexpression
- GSE224275 Effects on the transcriptome of mouse embryonic fibroblasts after both Son overexpression and knockdown and treatment with 3μM nintedanib, 1μM ponatinib, 3μM proflavine hemisulfate, and 1μM pyrvinium pamoate 43 samples shares overexpression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.