GEO series
Effect of a natural product derivative on gene expression signatures in 5xFAD transgenic mice
GSE296886
Mus musculus
Expression profiling by high throughput sequencing
25 samples
2025/05/13
GPL24247
Summary
To investigate how a natural product analog mitigates AD, cortical transcriptomes from WT and 5xFAD mice were analyzed. Comparing vehicle-treated groups revealed extensive differential expression associated with neuroinflammation in 5xFAD mice. This was attenuated in the 5xFAD mice treated with the natural product, whose profiles resembled WT controls. RNA seq suggested the natural product regulated the nervous and immune systems.
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