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Empagliflozin in acute myocardial infarction reduces no-reflow and preserves cardiac function by preventing endothelial damage

GSE255933 Mus musculus (mouse) RNA-seq (gene expression) 38 samples Submitted 2024/09/13 Platform GPL21626
At a glance

RNA-seq (gene expression) · mouse · 38 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
38 samples: 9 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Empagliflozin in Acute Myocardial Infarction Reduces No-Reflow and Preserves Cardiac Function by Preventing Endothelial DamageJACC. Basic to translational science · 2025
Summary (written by the submitters)
Myocardial infarct size (IS) and now reflow are major determinants of prognosis and currently there are no effective treatments. We investigated the effects of empagliflozin on cardiac cell populations affected by myocardial ischemia reperfusion injury (IRI), and its cardioprotective potential in terms of IS and no-reflow.
Published in
Empagliflozin in Acute Myocardial Infarction Reduces No-Reflow and Preserves Cardiac Function by Preventing Endothelial Damage
Nikolaou PE, Konijnenberg LSF, Kostopoulos IV et al. · JACC. Basic to translational science 2025 · PMID 39958474 · doi:10.1016/j.jacbts.2024.08.003
This dataset
Open GSE255933 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255933_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1077267 and SRA study SRP489988. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 39958474) ↗
Study design
9 conditions, mostly with about 4 replicates each
Cardiomyocytes, Control_I ×5 Endothelial Cells, EMPA_I ×5 Cardiomyocytes, SHAM ×4 Cardiomyocytes, EMPA_I ×4 Endothelial Cells, SHAM ×4 Endothelial Cells, Control_I ×4 Sorted Fibroblasts, SHAM ×4 Sorted Fibroblasts, Control_I ×4 +1 more

Supports a between-group comparison across 38 samples.

How we read this: 9 replicated groups read from 38 sample titles; they account for 38 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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