Persistent epigenome anomalies in induced pluripotent stem cells from late-onset sporadic Alzheimer’s disease cases
DNA methylation · human · 58 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 58 samples: 18 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255985_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1077342 and SRA study SRP490059. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 39 samples.
How we read this: 18 replicated groups read from 58 sample titles; they account for 39 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8083760 SCGB2160
- GSM8083761 SCAD2260
- GSM8083762 GB21J10_a
- GSM8083763 GB21J10_b
- GSM8083764 AD1_1J10_a
- GSM8083765 AD1_1J10_b
- GSM8083766 AD2_1J10_a
- GSM8083767 AD2_1J10_b
- GSM8083768 GB17J10_a
- GSM8083769 GB17J10_b
- GSM8083770 GB19J10_a
- GSM8083771 GB19J10_b
- GSM8083772 LGJ10_a
- GSM8083773 LGJ10_b
- GSM8083774 GB1410_1 GB1410
- GSM8083775 GB1410_2 GB1410
- GSM8083776 GB2_1_2 GB2_1
- GSM8083777 GB2_1_1 GB2_1
- GSM8083778 GB16_1_1
- GSM8083779 GB1_4_2 GB1_4
- GSM8083780 GB1_4_1 GB1_4
- GSM8083781 AD17_1_2 AD17_1
- GSM8083782 AD17_1_1 AD17_1
- GSM8083783 AD1_1_2 AD1_1
- GSM8083784 AD1_1_1 AD1_1
- GSM8083785 AD2_2_2 AD2_2
- GSM8083786 AD2_2_1 AD2_2
- GSM8083787 AD18_1_2 AD18_1
- GSM8083788 AD18_1_1 AD18_1
- GSM8083789 LG2 LG
- GSM8083790 LG1 LG
- GSM8083791 GB14NJ301 GB14NJ
- GSM8083792 GB14NJ302 GB14NJ
- GSM8083793 GB14NJ303 GB14NJ
- GSM8083794 G1_P5
- GSM8083795 G2_P5_1 G2_P5
- GSM8083796 G2_P5_2 G2_P5
- GSM8083797 A22_P5_2 A22_P5
- GSM8083798 A22_P5_1 A22_P5
- GSM8083799 LGNJ303 LGNJ
+ 18 more — browse all 58 samples with per-sample file links →
- GSE255982 Persistent epigenome anomalies in induced pluripotent stem cells from late-onset sporadic Alzheimer’s disease cases [RNA-seq] 52 samples shares pluripotent, persistent, late-onset, epigenome, anomalies, alzheimer, sporadic, induced
- GSE253337 Mitochondrial anomalies in induced pluripotent stem cells from Alzheimer’s disease cases with Presenilin 1 mutation 36 samples shares pluripotent, anomalies, alzheimer, induced
- GSE324961 microRNA-132 attenuates inflammation in induced pluripotent stem-cell derived microglia from Alzheimer’s disease patients 95 samples shares pluripotent, alzheimer, induced
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares pluripotent, induced
- GSE226482 Single cell RNA sequencing of spinal motor neurons and interneurons differentiated from isogenic FUS and TARDBP human induced pluripotent stem cell lines harbouring ALS-causative mutations 1415 samples shares pluripotent, induced
- GSE293777 A high-risk osteoarthritis mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells 84 samples shares pluripotent, induced
- GSE293032 Transcriptomic comparison of hepatocytes derived from a panel of human induced pluripotent stem cells with different ethnicities 54 samples shares pluripotent, induced
- GSE262710 Identifying SETBP1 haploinsufficiency molecular pathways to improve patient diagnosis using induced pluripotent stem cells and neural disease modelling. 46 samples shares pluripotent, induced
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.