m6A Reader IGF2BP3 Regulates Histone-to-protamine Replacement through RNA Translation Repression during Mouse Sperm Development
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 14 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IGF2BP3 recognizes m(6)A to regulate histone-to-protamine replacement during mouse sperm developmentThe EMBO journal · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE256055_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1077947 and SRA study SRP490309. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 16 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8084815 Igf2bp3+/-, replicate 1, RNA-seq
- GSM8084816 Igf2bp3+/-, replicate 2, RNA-seq
- GSM8084817 Igf2bp3+/-, replicate 3, RNA-seq
- GSM8084818 Igf2bp3-/-, replicate 1, RNA-seq
- GSM8084819 Igf2bp3-/-, replicate 2, RNA-seq
- GSM8084820 Igf2bp3-/-, replicate 3, RNA-seq
- GSM8084821 Igf2bp3+/-, replicate 1, RNC-seq
- GSM8084822 Igf2bp3+/-, replicate 2, RNC-seq
- GSM8084823 Igf2bp3+/-, replicate 3, RNC-seq
- GSM8084824 Igf2bp3-/-, replicate 1, RNC-seq
- GSM8084825 Igf2bp3-/-, replicate 2, RNC-seq
- GSM8084826 Igf2bp3-/-, replicate 3, RNC-seq
- GSM8569618 Testis,input,rep1
- GSM8569619 Testis,input,rep2
- GSM8569620 Testis,IGF2BP3,eCLIP,rep1
- GSM8569621 Testis,IGF2BP3,eCLIP,rep2
- GSE221643 Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control 16 samples shares translation, sperm
- GSE294418 PAN2 Maintains mRNA PolyA Tail Homeostasis and Regulates Translation during Spermiogenesis in Mouse 12 samples shares translation, sperm
- GSE302913 EIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis [Ribo-Seq] 6 samples shares translation, sperm
- GSE279846 Zbtb16 determines the fate plasticity of cardiovascular progenitors through IGF2BP3-mediated mRNA stabilization [scRNA-seq] 2 samples shares igf2bp3
- GSE265957 Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain 96 samples shares translation
- GSE318098 DDX3X-Mediated Translation of Structured Cardiac mRNAs is Essential for Female Heart Development [Ribo-Seq] 12 samples shares translation
- GSE314859 The degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos 67 samples shares translation
- GSE327880 Neuronal activation triggers rapid biphasic FMRP-mediated translational control linking synaptic and nuclear regulation 51 samples shares translation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.