Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Spermidine-eIF5A axis is essential for muscle stem cell activation via translational controlCell discovery · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE221643_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA915107 and SRA study SRP414544. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6892032 Polysome-Seq WT1, replicate1
- GSM6892033 Polysome-Seq WT2, replicate2
- GSM6892034 Polysome-Seq KO1, replicate1
- GSM6892035 Polysome-Seq KO2, replicate2
- GSM6892036 Ribo-Seq WT1, replicate1
- GSM6892037 Ribo-Seq WT2, replicate2
- GSM6892038 Ribo-Seq KO1, replicate1
- GSM6892039 Ribo-Seq KO2, replicate2
- GSM6892040 RNA-Seq WT1_1, WT1_2, replicate1
- GSM6892041 RNA-Seq WT2_1, WT2_2, replicate2
- GSM6892042 RNA-Seq WT3_1, WT3_2, replicate3
- GSM6892043 RNA-Seq K1_1, K1_2, replicate1
- GSM6892044 RNA-Seq K2_1, K2_2, replicate2
- GSM6892045 RNA-Seq K3_1, K3_2, replicate3
- GSM6892046 QSC
- GSM6892047 ASC
- GSE306935 The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo Regeneration 12 samples shares activation, muscle, stem
- GSE327880 Neuronal activation triggers rapid biphasic FMRP-mediated translational control linking synaptic and nuclear regulation 51 samples shares translational, activation, control
- GSE250460 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells 20 samples shares activation, muscle, stem
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares activation, muscle
- GSE276628 Reciprocal genetic screens identify epigenetics factors controlling epidermal cell activation. [RNAseq_MiniBulk] 41 samples shares activation, control
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares activation, stem
- GSE313021 STING–IFN–CH25H lipid axis links innate immune activation to tau pathology [scRNA-seq] 16 samples shares activation, axis
- GSE222941 Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration [RNA-seq: wildtype_EMCN] 11 samples shares essential, stem
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.