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Genes regulated by pharmacological Wnt activation by CHIR99021 in the embryonic mouse cochlea

GSE256069 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/01 Platform GPL21103
Summary
Our studies showed that Wnt activation influenced patterning of the mouse cochlea across the radial axis. To identify genes responding to Wnt activation, mouse embryonic cochleas were treated in the presence and absence of the GSK 3beta inhibitor, CHIR99021. Cochleas were harvested on E12.5 and cultured in vitro for 24 hours. On the next day (day 1), cochleas were treated with either DMSO vehicle control or CHIR99021. The 6-hour treatment helped to identify the immediate genes transcribed following Wnt activation.
Published in
A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2
Young CA, Burt E, Munnamalai V · Development (Cambridge, England) 2024 · PMID 39254648 · doi:10.1242/dev.202635
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Also filed as BioProject PRJNA1077987 and SRA study SRP490333. Searching any of these in the dataset finder brings you back here.

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