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Effect of GSK3 inhibition on the transcriptional signature of human GM-CSF-dependent monocyte-derived macrophages

GSE256208 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/16 Platform GPL23227
Summary
The functional versatility of macrophages is intrincately tied to factors such as their ontogeny and the specific tissue and extracellular environment. Monocyte-derived macrophages are oppositely instructed by M-CSF or GM-CSF. GM-CSF drives monocyte-derived macrophages towards heightened pro-inflammatory activity and the acquisition of the lung alveolar macrophage phenotype and gene profile whereas M-CSF gives rise to anti-inflammatory, pro-resolving, and immunosuppressive monocyte-derived macrophages. We explored the molecular impact of blocking GSK3 on the gene expression profile in GM-CSF-primed human monocyte derived macrophages. GSK3 inhibition skewed the transcriptional profile of GM-MØ towards an anti-inflammatory phenotype.
Published in
Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation
Ríos I, Herrero C, Torres-Torresano M et al. · eLife 2025 · PMID 40365863 · doi:10.7554/eLife.102659
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Also filed as BioProject PRJNA1078416 and SRA study SRP490573. Searching any of these in the dataset finder brings you back here.

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