The role of phagocyte NADPH Oxidase (NOX2) in modulating the antimicrobial and inflammatory functions of mouse neutrophils
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × WT Uninfected Neutrophil vs 3 × WT Infected Neutrophil vs 3 × Nox2 Uninfected Neutrophil vs 3 × Nox2 Infected NeutrophilGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infectionsMucosal immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE256399_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1079342 and SRA study SRP491236. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8097097 WT Uninfected Neutrophil Replicate 1 WT Uninfected Neutrophil
- GSM8097098 WT Uninfected Neutrophil Replicate 2 WT Uninfected Neutrophil
- GSM8097099 WT Uninfected Neutrophil Replicate 3 WT Uninfected Neutrophil
- GSM8097100 WT Infected Neutrophil Replicate 1 WT Infected Neutrophil
- GSM8097101 WT Infected Neutrophil Replicate 2 WT Infected Neutrophil
- GSM8097102 WT Infected Neutrophil Replicate 3 WT Infected Neutrophil
- GSM8097103 Nox2 Uninfected Neutrophil Replicate 1 Nox2 Uninfected Neutrop…
- GSM8097104 Nox2 Uninfected Neutrophil Replicate 2 Nox2 Uninfected Neutrop…
- GSM8097105 Nox2 Uninfected Neutrophil Replicate 3 Nox2 Uninfected Neutrop…
- GSM8097106 Nox2 Infected Neutrophil Replicate 1 Nox2 Infected Neutrophil
- GSM8097107 Nox2 Infected Neutrophil Replicate 2 Nox2 Infected Neutrophil
- GSM8097108 Nox2 Infected Neutrophil Replicate 3 Nox2 Infected Neutrophil
- GSE313699 Loss of NADPH-producing enzymes accelerates pancreatic precancerous lesions 14 samples shares nadph
- GSE234176 Role of growth plate Nox2 in alcoholic osteopenia 12 samples shares nox2
- GSE315519 Taldo1 Knockdown impaired NADPH production in CD8+ T cells 6 samples shares nadph
- GSE278570 Neutrophils physically interact with tumor cells to form a signaling niche promoting breast cancer aggressiveness 309 samples shares neutrophils
- GSE301965 Type I IFN impedes early bacterial control in TB-resistant and -susceptible mice and activates neutrophils to restrict lung macrophage-T cell interactions 72 samples shares neutrophils
- GSE298786 Type I IFN impedes early bacterial control in TB-resistant and -susceptible mice and activates neutrophils to restrict lung macrophage-T cell interactions [RNA-seq] 70 samples shares neutrophils
- GSE280057 Gene expression profile at single cell level of tumor-infiltrating neutrophils (TINs) of cholangiocarcinoma (CCA) tumors 52 samples shares neutrophils
- GSE295728 Vaccination against Onchocerca volvulus induces IgG-mediated protective immunity dependent on neutrophils and complement 47 samples shares neutrophils
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.