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Exploring PDE5A upregulation in bipolar disorder: insights from single-nuclei RNA sequencing of human basal ganglia

GSE260513 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/28 Platform GPL24247
Summary
The basal ganglia has been considered as a potential target implicated in bipolar disorder (BD), but there is currently limited research on molecular changes. In this study, we conducted single-nucleus RNA sequencing on 30,752 nuclei from the putamen, caudate nucleus, pallidum, and substantia nigra of postmortem brains without apparent neurological and psychiatric disorders, as well as 24,672 nuclei from the same brain regions of BD patients. By performing differential expression analysis, weighted gene co-expression network analysis (WGCNA), single-cell regulome analysis (SCENIC), and CellChat analysis, we investigated the cell type-specific gene expression and network changes in the basal ganglia of BD patients compared to healthy individuals. These findings provide an important direction for the study of bipolar disorder.
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Direct links to NCBI, no account and no request form: the whole study as GSE260513_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1081911 and SRA study SRP492410. Searching any of these in the dataset finder brings you back here.

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